Publications

  • Wright M, Redford M, Vehar J, Courtney KC, Billington N, Liu R. (2024) Protocols for MultiBac System-based Purification and Biophysical Characterization of Human Myosin-7a. Journal of Visualized Experiments (210), e67135, doi:10.3791/67135

  • Courtney KC, Mandal T, Mehta N, Wu L, Li Y, Das D, Cui Q, Chapman ER. (2023) Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration. Nat Commun 14, 7761. https://doi.org/10.1038/s41467-023-42497-8

  • Courtney KC*, Wu L*, Mandal T, Swift M, Zhang Z, Alaghemandi M, Wu Z, Bradberry MM, Deo C, Lavis LD, Volkmann N, Hanein D, Cui Q, Bao H, Chapman ER. (2022) The complexin C-terminal amphipathic helix stabilizes the fusion pore open state by sculpting membranes. Nature Structural & Molecular Biology 29, 97–107. https://doi.org/10.1038/s41594-021-00716-0.

  • Courtney KC*, Vevea JD*, Li Y*, Wu Z, Zhang Z, Chapman ER. (2021) Synaptotagmin 1 oligomerization via the juxtamembrane linker regulates spontaneous and evoked neurotransmitter release. Proceedings of the National Academy of Sciences 118 (48) e2113859118; https://doi.org/10.1073/pnas.2113859118.

  • Vevea JD, Kusick GF, Courtney KC, Chen E, Watanabe S, Chapman ER. (2021) Synaptotagmin 7 is enriched at the plasma membrane to promote vesicle docking and control synaptic plasticity. eLife 2021;10:e67261 DOI: 10.7554/eLife.67261

  • Wu L, Courtney KC, Chapman ER. (2021) Cholesterol stabilizes recombinant exocytic fusion pores by altering membrane bending rigidity. Biophysical Journal, 120(8). DOI: 10.1016/j.bpj.2021.02.005.

  • Liu L*, Courtney KC*, Huth SW, Rank LA, Weisblum B, Chapman ER, Gellman SH. (2021) Beyond Amphiphilic Balance: Changing Subunit Stereochemistry Alters the PoreForming Activity of Nylon-3 Polymers. Journal of the American Chemical Society, 143(8). DOI: 10.1021/jacs.0c12731.

  • Das D, Bao H, Courtney KC, Wu L, Chapman ER. (2020) Resolving kinetic intermediates during the regulated assembly and disassembly of fusion pores. Nature Communications, 11(231). DOI: 10.1038/s41467-019-14072-7.

  • Courtney KC, Fung KY, Maxfield FR, Fairn GD, Zha X. (2018) Comment on "Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol. eLife, 7, 8, DOI: 10.7554/eLife.38493.

  • Courtney KC, Pezeshkian W, Raghupathy R, Zhang C, Darbyson A, Ipsen, JH, Ford DA, Khandelia H, Presley JF, Zha X. (2018) C24 sphingolipids govern the transbilayer asymmetry of cholesterol and lateral organization of model and live cell plasma membranes. Cell Reports, 24(4), 1037-1049. DOI: 10.1016/j.celrep.2018.06.104.

  • Eid W, Dauner K, Courtney KC, Gagnon A, Parks RJ, Sorisky A, Zha X (2017) mTORC1 Activates SREBP-2 by Suppressing Cholesterol Trafficking to the Lysosomes in Mammalian Cells. Proceedings of the National Academy of Sciences, 114(30), 7999- 8004. DOI: 10.1073/pnas.1705304114.

  • Dong F, Mo Z, Eid W, Courtney KC, Zha X (2014) Akt Inhibition Promotes ABCA1- Mediated Cholesterol Efflux to ApoA-I through Suppressing mTORC1. PLOS ONE 9(11): e113789. DOI: 10.1371/journal.pone.0113789.